Celiac Disease Diagnostic Panel

Test Code

15681

Includes

Tissue Transglutaminase (tTG) Antibodies (IgG, IgA)
Gliadin (Deamidated) Antibody (IgG, IgA)
IgA (Immunoglobulin A)

Preferred Specimen

Red Top

Minimum Volume

1.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology
Immunoassay (IA) • Immunoturbidimetric Assay

Reference Range

Tissue Transglutaminase Antibody, IgG

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

Tissue Transglutaminase Antibody, IgA

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

Gliadin (Deamidated) Antibody (IgG)

<15.0 U/mL			Antibody not detected
≥15.0 U/mL			Antibody detected

Gliadin (Deamidated) Antibody (IgA)

<15.0 U/mL			Antibody not detected
≥15.0 U/mL			Antibody detected

IgA (Immunoglobulin A)

Cord Blood	Not Established
≤3 months	5-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

Clinical Significance

Celiac disease is characterized by the presence of Transglutaminase, Gliadin, and Reticulin Antibodies. Such patients display a hypersensitivity to gluten (wheat) in their diet. The antibody is undetectable when patients with hypersensitivity are placed on gluten-free diets. Antibody IgA is more specific and IgG is more sensitive to Celiac disease.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.