Myelopathy, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid

Test Code
12889


CPT Codes
84182, 86053, 86255 (x16), 86341<br>Restricted Client Code

Includes

If indirect immunofluorescence assay (IFA) pattern suggests anti-glial nuclear antibody (AGNA-1), then AGNA-1 immunoblot and AGNA-1 IFA titer will be performed at an additional charge.

If IFA pattern suggests amphiphysin antibody, then amphiphysin immunoblot and amphiphysin IFA titer will be performed at an additional charge.

If IFA pattern suggests anti-neuronal nuclear antibody type 1 (ANNA-1), then ANNA-1 immunoblot, ANNA-1 IFA titer, and ANNA-2 immunoblot will be performed at an additional charge.

If IFA pattern suggests ANNA-2 antibody, then ANNA-2 immunoblot, ANNA-2 IFA titer, and ANNA-1 immunoblot will be performed at an additional charge.

If client requests or the IFA pattern suggests ANNA-3 antibodies, then ANNA-3 IFA titer will be performed at an additional charge.

If IFA pattern suggests adaptor protein 3 beta 2 (AP3B2) antibodies, then AP3BC cell-binding assay (CBA) and AP3BC IFA titer will be performed at an additional charge.

If collapsin response-mediator protein 5 (CRMP-5)-IgG Western blot is positive, then CRMP-5-IgG IFA titer will be performed at an additional charge.

If IFA pattern suggests Purkinje cell cytoplasmic antibody type 1 (PCA-1), then PCA-1 immunoblot and PCA-1 IFA titer will be performed at an additional charge.

If IFA pattern suggests PCA-2 antibody, then PCA-2 IFA titer will be performed at an additional charge.

If IFA pattern suggests N-methyl-D-aspartate (NMDA) receptor antibody, then NMDA-receptor antibody CBA and NMDA-receptor antibody IFA titer will be performed at an additional charge.

If gamma-aminobutyric acid B (GABA-B) receptor antibody CBA is positive, then GABA-B-receptor antibody IFA titer will be performed at an additional charge.

If IFA pattern suggests dipeptidyl-peptidase-like protein-6 (DPPX) antibody, then DPPX antibody CBA and DPPX antibody IFA titer will be performed at an additional charge.

If IFA pattern suggests metabotropic glutamate receptor 1 (mGluR1) antibody, then mGluR1 antibody CBA and mGluR1 antibody IFA titer will be performed at an additional charge.

If IFA pattern suggests glial fibrillary acidic protein (GFAP) antibody, then GFAP antibody CBA and GFAP antibody IFA titer will be performed at an additional charge.

If the neuromyelitis optica/aquaporin-4-IgG (NMO/AQP4-IgG) fluorescence-activated cell sorting (FACS) screen assay requires further investigation, then NMO/AQP4-IgG FACS titration assay will be performed at an additional charge.

If IFA pattern suggests neuronal intermediate filament (NIF) antibody, then alpha internexin CBA, NIF heavy chain CBA, NIF light chain CBA, and NIF antibody IFA titer will be performed at an additional charge.

If IFA pattern suggests neurochondrin antibody, then neurochondrin antibody CBA and neurochondrin IFA titer will be performed at an additional charge.

If IFA pattern suggests septin 7 antibody, then septin 7 CBA and septin 7 IFA titer will be performed at an additional charge​.



Preferred Specimen
4 mL CSF collected in a sterile transport tube


Minimum Volume
2 mL


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Gross icterus


Methodology
Cell-binding Assay • Indirect Immunofluorescence Assay • Immunoblot (IB) • Western Blot (WB)

Setup Schedule
Set up: Daily; Report available: 8-12 days


Reference Range
See Laboratory Report




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.