A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

DOG1, IHC with Interpretation

Test Code
90161


CPT Codes
88342

Preferred Specimen
1 formalin-fixed, paraffin-embedded, tissue block submitted in an IHC Specimen Transport Kit


Minimum Volume
1 block


Other Acceptable Specimens
3 unstained slides, positively charged, submitted in an IHC Specimen Transport Kit


Instructions
Please include surgical pathology report


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Methodology
Immunohistochemistry

Setup Schedule
Set up: Mon-Fri; Report available: 3 days


Reference Range
See Laboratory Report


Clinical Significance
DOG1 antibodies detect anoctamin 1, a marker of gastrointestinal stromal tumors that may be more sensitive (85-90% immunoreactive) than c-KIT antibodies (approximately 75%) or CD34 (approximately 70%), especially in the PDGFRA-mutated subgroup of GISTs. It is especially useful in the differential diagnosis with leiomyosarcoma and synovial sarcomas, which are nearly always negative for DOG1.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.