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BOB1, IHC without Interpretation [19417X]
Test Code19417
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted in an IHC specimen transport kit
Other Acceptable Specimens
3-micron unstained sections on Poly-L-Lysine or Silane coated slides, (+) positively charged slides
Instructions
Do not place paper labels with adhesive backing on slides. Use pencil or xylene-resistant pen to write on the frosted end of the slide only.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Clinical Significance
Expression of the BOB.1/OBF.1 transcriptional coactivator is restricted largely to B cells in the germinal centers and to plasma cells but is overexpressed in many B-cell lymphoma subtypes. It is most helpful in distinguishing T-cell rich B-cell lymphoma (strongly positive) from classical Hodgkin lymphoma (weak/negative), usually in association with staining for other B-cell markers.
