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Borrelia Species DNA, Real-Time PCR, with Reflexes, Synovial Fluid/CSF
Test Code39218
CPT Codes
87801
Includes
If Borrelia Species DNA, Real-Time PCR is Detected, then Borrelia burgdorferi DNA, Qualitative Real-Time PCR, Miscellaneous and Borrelia miyamotoi DNA, Real-Time PCR, Miscellaneous will be performed at an additional charge (CPT Code(s): 87476, 87478)
Preferred Specimen
3 mL CSF or synovial fluid collected in a sterile plastic leak-proof container
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
Not detected
Clinical Significance
This test is intended for the qualitative detection of Borrelia DNA in whole blood, CSF, synovial fluid, or ticks. Borrelia are spirochetes and are commonly classified into two categories: those that cause Lyme disease (Lyme borreliosis) and those that cause relapsing fever. This test detects species in both categories.
Borrelia are typically transmitted to humans via the bite of an infected tick, including hard-bodied ticks of the genera Amblyomma and Ixodes and soft-bodied ticks of the genera Ornithodoros.
Lyme disease, the most common tick-borne infection in the United States, is marked by three stages: 1) local infection, which can include an erythema migrans or "bull's eye" skin lesion and/or flulike symptoms; 2) disseminated infection, which is typically marked by cardiac, neurological and/or skin manifestations; and 3) persistent infection, which can include Stage 2 manifestations as well as rheumatological involvement, most commonly joint pain.
Relapsing fever is marked by febrile periods lasting about three days that alternate with afebrile periods include muscle and joint pain, headache, vomiting and dizziness.
Diagnosis of Borrelia infections is normally based on clinical findings and serological assays. PCR testing can serve as an adjunct to serology, especially during the early stages of infection before antibodies have developed.
Borrelia are typically transmitted to humans via the bite of an infected tick, including hard-bodied ticks of the genera Amblyomma and Ixodes and soft-bodied ticks of the genera Ornithodoros.
Lyme disease, the most common tick-borne infection in the United States, is marked by three stages: 1) local infection, which can include an erythema migrans or "bull's eye" skin lesion and/or flulike symptoms; 2) disseminated infection, which is typically marked by cardiac, neurological and/or skin manifestations; and 3) persistent infection, which can include Stage 2 manifestations as well as rheumatological involvement, most commonly joint pain.
Relapsing fever is marked by febrile periods lasting about three days that alternate with afebrile periods include muscle and joint pain, headache, vomiting and dizziness.
Diagnosis of Borrelia infections is normally based on clinical findings and serological assays. PCR testing can serve as an adjunct to serology, especially during the early stages of infection before antibodies have developed.
