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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
FusionSEQ Panel
Test Code12353
Preferred Specimen
**This test is not available for New York or Rhode Island
patient testing.**
Instructions:
Do not freeze. Do not reject.
Submit in sterile biohazard plastic bag at room temperature
or on ice pack in summer. Specimen to be tested should
contain a minimum of 10 percent tumor nuclei.
All specimens must be accompanied with Pathology report.
All FFPE specimens will be examined by a pathologist for
confirmation and adequacy. Macrodissection if warranted is
performed in the lab.
Reject Criteria:
Decalcified tissue specimen
PREFERRED
6-10 slides (10-micron sections) for resection or surgical
specimens with H&E slide in slide holder, room temperature
or refrigerated (cold packs)
--or--
10-20 slides (10-micron sections) for core needle biopsies
in slide holder, room temperature or refrigerated (cold
packs)
--or--
ACCEPTABLE
Paraffin-embedded tissue block accompanied by a circled H&E
slide indicating the area to be examined, room temperature
or refrigerated (cold packs)
RT: Preferred
Refrigerated (cold packs): Acceptable
Frozen: Unacceptable
patient testing.**
Instructions:
Do not freeze. Do not reject.
Submit in sterile biohazard plastic bag at room temperature
or on ice pack in summer. Specimen to be tested should
contain a minimum of 10 percent tumor nuclei.
All specimens must be accompanied with Pathology report.
All FFPE specimens will be examined by a pathologist for
confirmation and adequacy. Macrodissection if warranted is
performed in the lab.
Reject Criteria:
Decalcified tissue specimen
PREFERRED
6-10 slides (10-micron sections) for resection or surgical
specimens with H&E slide in slide holder, room temperature
or refrigerated (cold packs)
--or--
10-20 slides (10-micron sections) for core needle biopsies
in slide holder, room temperature or refrigerated (cold
packs)
--or--
ACCEPTABLE
Paraffin-embedded tissue block accompanied by a circled H&E
slide indicating the area to be examined, room temperature
or refrigerated (cold packs)
RT: Preferred
Refrigerated (cold packs): Acceptable
Frozen: Unacceptable
Methodology
Next Generation Sequencing Anchored Multiplex PCR (AMP(TM))
Setup Schedule
Monday-Sunday Morning
Report available: 11 Days
Report available: 11 Days
Reference Range
See Laboratory Report
Clinical Significance
The FusionSEQ assay detects the presence of known and
novel gene rearrangements (fusions) and exon skipping
events in clinically relevant genes associated with the
pathogenesis of many pediatric and adult solid tumor
malignancies. FDA approved therapies and clinical trials
are available for patients with these genomic
abnormalities in certain solid tumors, and the detection
of these abnormalities is beneficial in the management of
disease and survival of the patient.
novel gene rearrangements (fusions) and exon skipping
events in clinically relevant genes associated with the
pathogenesis of many pediatric and adult solid tumor
malignancies. FDA approved therapies and clinical trials
are available for patients with these genomic
abnormalities in certain solid tumors, and the detection
of these abnormalities is beneficial in the management of
disease and survival of the patient.
