Neuropeptide Y

Test Code

16059

CPT Codes
83519<br>Limited Access Code<br>This test is not available for New York patient testing.

Preferred Specimen

3 mL frozen plasma collected in a 10 mL InterScience Institute's (ISI) Z-tube™ Preservative

Patient Preparation
Patient should be fasting 10-12 hours prior to collection of specimen. Medications that affect insulin secretion or gastrointestinal function should be discontinued, if possible, for at least 48 hours prior to collection.

Minimum Volume

1 mL

Instructions

Collect 10 mL blood directly into ISI's Z-tube™ Preservative and separate as soon as possible. Freeze plasma immediately after separation. Special Z-tube™ Preservatives are available from Inter Science Institute (ISI).

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Transport Temperature

Frozen

Specimen Stability

Room temperature: 1 hour
Refrigerated: 1 hour
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemia • Grossly icteric • Received room temperature • Received refrigerated • Not collected in a Z-tube™

Methodology
Direct Radioimmunoassay

FDA Status

This test has not been cleared or approved by the US Food and Drug Administration. The reference interval has been established using the ISI preservative indicated for this test. No other sample types are acceptable.

This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

Setup Schedule

Set up: Varies; Report available: 15 days

Reference Range

154-513 pg/mL

Clinical Significance

Neuropeptide Y is a 36 amino acid peptide very similar throughout all species of mammals. It is found primarily in the sympathetic nervous system, gut, and brain. Neuropeptide Y is closely related structurally to Peptide YY and Vasoactive Intestinal Polypeptide. Neuropeptide Y has key roles in cardiovascular and hypothalamic function. It potentiates vasoconstriction, causing an increase in blood pressure. Levels are increased by stress, Dexamethasone, septic shock, relaxation of colon, Atrial Natriuretic Factor, water and sodium secretion, Luteinizing Hormone and ACTH. Levels are inhibited by amphetamines, and are decreased in patients with Alzheimer's disease. Neuropeptide Y inhibits Norepinephrine, the effect of Cholecystokinin, Renin release, Insulin and Glucagon secretion, and the Melanotropins. Actions of Neuropeptide Y are enhanced by a2 adrenoreceptor agonists.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.