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Ghrelin, Total (Plasma)
Test Code17824
CPT Codes
83520<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
3-5 mL plasma (See Collection Instructions)
Patient Preparation
Patient should be fasting for 10-12 hours prior to collection of specimen.
Patient should not be on any medications or supplements that may influence: Cholecystokinin (CCK), Glucose, Growth Hormone, Insulin and/or Somatostatin levels, if possible, for at least 48 hours prior to collection.
Minimum Volume
1 mL
Instructions
Collect 10 mL blood in special ISI GI preservative tube yielding special GI plasma and separate in refrigerated centrifuge as soon as possible. Transfer 3-5 mL immediately into non-glass shipping vial. Freeze specimen at -20° C. Variance from these instructions must be disclosed to ISI prior to specimen analysis.
Non-refrigerated centrifuge
Collect 10 mL blood in special ISI GI preservative tube, invert tube gently several times. Return the tubes to the ice or refrigerate (2-8° C) for 15 minutes. Centrifuge ice-cold tubes to separate GI plasma. Recommended 1057 g for 10 minutes. After centrifugation, return tubes to the ice. Aliquot and freeze aliquoted plasma immediately. Ship frozen specimens frozen via overnight courier service with sufficient dry ice.
Non-refrigerated centrifuge
Collect 10 mL blood in special ISI GI preservative tube, invert tube gently several times. Return the tubes to the ice or refrigerate (2-8° C) for 15 minutes. Centrifuge ice-cold tubes to separate GI plasma. Recommended 1057 g for 10 minutes. After centrifugation, return tubes to the ice. Aliquot and freeze aliquoted plasma immediately. Ship frozen specimens frozen via overnight courier service with sufficient dry ice.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 24 days
Frozen: 6 months
Refrigerated: 24 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly Icteric
Methodology
RIA
FDA Status
This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.
Setup Schedule
Set up: Varies; Report available: 4-6 business days
Reference Range
See Medical Report
Clinical Significance
Ghrelin is a novel 28 amino acid peptide derived by post-translational processes from a preproghrelin consisting of 117 residues, secreted by the stomach with specific receptors in the brain involved in appetite regulation. It conveys information to the brain thereby increasing appetite, food intake and body weight and influences the release of growth hormone. Ghrelin is a growth hormone-releasing peptide which acts as an endogenous ligand of the growth hormone secretagogue receptors (GHS-Rs). Ghrelin levels are inversely correlated with body weight and are higher during weight loss.
