FISH, Myeloma Panel with Reflex

Test Code

11943

CPT Codes
88271 (x13), 88275 (x6)

Includes

If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes(s): 88271 (x8), 88275 (x4)).

If results are not possible from the submitted specimen, the test order will be cancelled and replaced by non-orderable test Cytogenetics Communication.

Preferred Specimen

3 mL bone marrow collected in a sodium heparin (green-top) tube

Minimum Volume

1 mL

Other Acceptable Specimens

Bone marrow collected in: EDTA (lavender-top) tube

Instructions

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 7 days

Reference Range

See Laboratory Report

Clinical Significance

Plasma cell myeloma is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. This FISH panel is designed for clinical risk classification. Initial FISH testing is performed to detect deletion of TP53 (17p), rearrangements of IGH (14q32), rearrangements of MYC, gain of 1q, deletion of 1p, deletion 13q/monosomy 13, and gain (trisomy) of chromosome 9, 11, and 15 (for hyperdiploidy). When IGH rearrangement is positive, FISH for the specific IGH rearrangements t(11;14), t(4;14), t(14;16), t(14;20) will be performed.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.