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HLA B51 Behcet's Disease Association
Test Code12344
CPT Codes
81381
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Other Acceptable Specimens
Whole blood collected in: Sodium heparin (green-top) tube, EDTA (pink-top) tube, EDTA (royal blue-top) tube, or sodium citrate (light blue-top) tube
Instructions
If submitted with any other tests, please submit separate tube for this test. Do not open tube or split sample.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
Refrigerated: 7 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen • Clotted
Methodology
Polymerase Chain Reaction Amplification • Sequence Specific Oligonucleotide Probes
Setup Schedule
Set up: Daily; Report available: 8 days
Reference Range
See Laboratory Report
Clinical Significance
This syndrome due to multisystem chronic inflammatory disease of blood vessels has variable presentation of recurrent mouth ulcers, genital ulcers, inflammation of the eye (Uveitis), and gastrointestinal symptoms. HLA-B*51:02 shows the strongest association with the disease, but it is not diagnostic. The disease distribution is worldwide but clusters in the area that extends from Eastern Asia to the Mediterranean region (Silk Route disease).
Reference:
Takeno, Mitsuhiro. The association of Behet's syndrome with HLA-B51 as understood in 2021, Current Opinion in Rheumatology: January 2022 - Volume 34 - Issue 1 - p 4-9
Reference:
Takeno, Mitsuhiro. The association of Behet's syndrome with HLA-B51 as understood in 2021, Current Opinion in Rheumatology: January 2022 - Volume 34 - Issue 1 - p 4-9
