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Micronutrients, Antioxidants Panel
Test Code10187
CPT Codes
82180, 82542, 84446, 84590
Includes
10178 - Micronutrient, Coenzyme Q10 (CoQ10)
10179 - Micronutrient, Vitamin A (Retinol)
10181 - Micronutrient, Vitamin C
10183 - Micronutrient, Vitamin E (Alpha Tocopherol and Beta Gamma Tocopherol)
10179 - Micronutrient, Vitamin A (Retinol)
10181 - Micronutrient, Vitamin C
10183 - Micronutrient, Vitamin E (Alpha Tocopherol and Beta Gamma Tocopherol)
Preferred Specimen
3 mL serum submitted in an amber tube or wrap specimen tubes in aluminum foil - protected from light - (see instructions)
Patient Preparation
Overnight fasting required
Avoid taking Coenzyme Q10 supplements the morning of the test.
Refrain from eating fruits or taking vitamin C supplements 24 hours prior to collection.
Minimum Volume
1.5 mL
Instructions
Patients should be 18 years of age or greater.
Gently invert specimen 5 times (DO NOT SHAKE!), allow to clot for 30-60 minutes at room temperature, centrifuge 10 minutes.
Separate serum into 3 amber plastic transport tubes:
1 mL (0.5 mL min) for Vitamin A and E, protect from light, ship frozen (can be refrigerated).
1 mL (0.5 mL min) for Vitamin C, freeze immediately, protect from light, ship frozen.
1 mL (0.5 mL min) for CoQ10, protect from light, ship refrigerated. Do not ship on dry ice.
Coenzyme Q10 must NOT be shipped on dry ice.
Vitamin C must be shipped on dry ice. Additionally, for remote collection sites, or those with no access to ultra-low freezers or dry ice, it is recommended to schedule patient visits/draws after 12:00 p.m. local time and store the samples at -10° C to -30° C freezers (stable for 8 hours) until picked up by courier. Couriers should then transfer samples to -70° C storage (on dry ice) while enroute to the performing site location.
Gently invert specimen 5 times (DO NOT SHAKE!), allow to clot for 30-60 minutes at room temperature, centrifuge 10 minutes.
Separate serum into 3 amber plastic transport tubes:
1 mL (0.5 mL min) for Vitamin A and E, protect from light, ship frozen (can be refrigerated).
1 mL (0.5 mL min) for Vitamin C, freeze immediately, protect from light, ship frozen.
1 mL (0.5 mL min) for CoQ10, protect from light, ship refrigerated. Do not ship on dry ice.
Coenzyme Q10 must NOT be shipped on dry ice.
Vitamin C must be shipped on dry ice. Additionally, for remote collection sites, or those with no access to ultra-low freezers or dry ice, it is recommended to schedule patient visits/draws after 12:00 p.m. local time and store the samples at -10° C to -30° C freezers (stable for 8 hours) until picked up by courier. Couriers should then transfer samples to -70° C storage (on dry ice) while enroute to the performing site location.
Transport Temperature
Vitamins A and E, Coenzyme Q10: Refrigerated (cold packs)
Vitamin C: Frozen -70° C
Vitamin C: Frozen -70° C
Specimen Stability
Coenzyme Q10 (CoQ10)
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 6 weeks
Vitamin A and Vitamin E
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days
Vitamin C
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen -20° C: 8 hours
Frozen -70° C: 35 days
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 6 weeks
Vitamin A and Vitamin E
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days
Vitamin C
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen -20° C: 8 hours
Frozen -70° C: 35 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Received room temperature • Not protected from light • Vitamin C received refrigerated
Methodology
Chromatography • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Set up and Report available: See individual assays
Reference Range
| Coenzyme Q10 (CoQ10) | >35 ug/mL |
Vitamin A (Retinol)
| 18-19 years | 26-72 mcg/dL |
| >19 years | 38-98 mcg/dL |
Vitamin C
| Male ≥18 years | 0.2-2.1 mg/dL |
| Female ≥18 years | 0.3-2.7 mg/dL |
Vitamin E
| Vitamin E, Alpha Tocopherol | ≥18 years | 5.7-19.9 mg/L |
| Vitamin E, Beta-Gamma Tocopherol | ≥18 years | <4.4 mg/L |
