Hemoglobin A1C w/eAG

A1C

A1C

Hemoglobin A1c, Estimated Average Glucose

Lavender EDTA Whole Blood

0.5 mL

N/A

Lavender EDTA

Room Temperature

Room Temp: 3 Days; Refrigerated: 3 Days

•The design of VITROS HbA1c assay allows its use in patients with hemoglobin variants S, C, D and E traits. However, in case of disease condition such as HbSS, HbCC, or HbSC, even if the assay does not interefere with their variant, these patients may suffer anemia, increased red blood cell turnover, and transfusion requirements which can adversely affect HbA1c as a marker of long-term glycemic control. Any cause of shortened erythrocyte survival or decrease in mean erythrocyte age (e.g. recovery from acute blood loss, hemolytic anemia) will reduce exposure of erythrocytes to glucose with a consequent decrease in mmol/mol HbA1c (IFCC) and %A1c (DCCT/NGSP). Therefore, health care providers should not use the HbA1c test for these patients. Alternative forms of testing such as glycated serum protein or glycated albumin should be considered for these patients. •Hemoglobin A1c should not be used to diagnose diabetes mellitus in patients with malignancies or severe chronic
hepatic and renal disease. •Hemoglobin A1c should not be used in patients with homozygous sickle cell trait, hemolytic anemia, or other hemolytic
diseases and recent significant or chronic blood loss.

4.8-5.6%

HbA1c is the major species of glycohemoglobin found in human blood, and is formed by the non-enzymatic glycation of the free amino group at the N-terminal of the hemoglobin A0 ß-chain. 1 The percentage of HbA1c (%A1c) is widely used as a retrospective index of glycemic control in diabetic patients. 2 Studies have shown that glycemic control results in reduction in diabetic complications. 3 4 The glycation of hemoglobin depends on both the lifespan of the red blood cell and the blood glucose concentration. Since the rate of glycated hemoglobin formation is directly proportional to the concentration of glucose in the blood, the level of glycated hemoglobin is an index of the blood glucose concentrations over an extended period of time (~6 to 8 weeks).