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Transferrin
Test CodeLAB133
CPT Codes
84466
Preferred Specimen
4.5 ml (600 ul min) lithium heparin (green); alternate-SST (gold) or Red (no additive)
Minimum Volume
1 ml (200 ul minimum) plasma; alternate-serum
Instructions
After centrifugation, if not in gel barrier tube, pour off plasma or serum into an aliquot tube.
Transport Temperature
Room temp
Specimen Stability
Separated from cells: 7 days room temp, 7 days refrigerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Icteric: >40 mg/dL bilirubin, Hemolysis: >500 mg/dL hemoglobin, Lipemia: >1000 mg/dL
Methodology
Turbidimetric Immunoassay
Setup Schedule
Mon- Sun
Reference Range
192 - 382 mg/dL
Clinical Significance
Transferrin levels rise with iron deficiency and fall in cases of iron overload. An increase in transferrin is seen in
iron deficiency anemia. It may also be increased late in pregnancy and in women on oral contraceptives. It is
decreased in conditions associated with increased protein loss, such as nephrotic syndrome, chronic renal failure,
severe burns, and protein-deficiency states and in severe liver disease. Transferrin is a negative acute-phase protein
and will be decreased during any inflammatory state or severe illness.
iron deficiency anemia. It may also be increased late in pregnancy and in women on oral contraceptives. It is
decreased in conditions associated with increased protein loss, such as nephrotic syndrome, chronic renal failure,
severe burns, and protein-deficiency states and in severe liver disease. Transferrin is a negative acute-phase protein
and will be decreased during any inflammatory state or severe illness.
Performing Laboratory
Piedmont Athens Regional