A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Anti-Streptolysin O Antibody (ASO)
Test Code265
Alias/See Also
LAB219
CPT Codes
86060
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Container
Serum separator tube (SST)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Immunoturbidimetric
Setup Schedule
Tues-sat
Limitations
False-positive ASO titers can be due to increased levels of serum beta-lipoprotein produced in liver disease and by "contamination" of serum by Bacillus cereus and Pseudomonas species. ASO is not sensitive for the diagnosis of streptococcal pyoderma.
Reference Range
<5 Years | <100 IU/mL | |
5-20 Years | <250 IU/mL | |
≥21 Years | <200 IU/mL |
Clinical Significance
This test is a sensitive test for recent streptococcal infection. A rise in ASO begins about one week after infection and peaks two to four weeks later. ASO levels do not rise with cutaneous infections. In the absence of complications or reinfection, the ASO level will fall to preinfection levels within 6 to 12 months. Over 80% of patients with acute rheumatic fever and 95% of patients with acute glomerulonephritis due to streptococci have elevated levels of ASO.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |