Quantitative Thyroglobulin without Thyroglobulin Antibodies

15561

LAB533
THYROGLOBULIN

1 mL serum

0.5 mL

Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

Serum Separator Tube (SST)

Room temperature

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Tues-sat

Intact Thyroid	2.8-40.9 ng/mL
Athyrotic	<0.1 ng/mL

Note: Abnormal flagging is based on the reference interval for patients with intact thyroid.

Thyroglobulin (TG) is a secretory product only of the thyroid gland. The major clinical use of serum TG measurement is to monitor, but not to diagnose, patients with well-differentiated thyroid cancers. The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis. Deficient TG synthesis is observed in infants with goitrous hypothyroidism. With immunometric assays (sandwich assays), TGAB interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent Ab from binding endogenous TG.