Osteocalcin, N-MID

Message
SEND TO PROCESSING ASAP.
NO GEL.
GREATER THAN 8 HRS AFTER BIOTIN.

CENTRIFUGE AND FREEZE ALIQUOT ASAP.
NO HEMOLYSIS.


Test Code
16322


Alias/See Also
LAB1060


CPT Codes
83937

Preferred Specimen
1 mL serum


Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Minimum Volume
0.5 mL


Instructions
Allow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.


Transport Container
Transport tube


Transport Temperature
Frozen


Specimen Stability
Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen 21 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Heat inactivated specimens • Specimens stabilized with azide • Patient administered with biotin within 8 hours


Methodology
Electrochemiluminescence Immunoassay (ECLIA)

Setup Schedule
Mon-sat


Report Available
2-6 days


Reference Range
  Male
(ng/mL)
Female
(ng/mL)
0-4 Years Not established Not established
5-9 Years 47-142 47-142
10-13 Years 49-167 49-167
14-17 Years 26-203 14-85
>17 Years 9-38 8-32


Clinical Significance
Osteocalcin, the most abundant non-collagen protein in bone matrix, is a bone-specific, calcium binding protein. Serum osteocalcin levels are related to the rate of bone turnover in various disorders of bone metabolism, e.g., osteoporosis, primary and secondary hyperparathyroidism, and Paget's disease.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.