Osteocalcin, N-MID

Message

SEND TO PROCESSING ASAP.
NO GEL.
GREATER THAN 8 HRS AFTER BIOTIN.

CENTRIFUGE AND FREEZE ALIQUOT ASAP.
NO HEMOLYSIS.

Test Code

16322

Alias/See Also

LAB1060

CPT Codes
83937

Preferred Specimen

1 mL serum

Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Minimum Volume

0.5 mL

Instructions

Allow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Heat inactivated specimens • Specimens stabilized with azide • Patient administered with biotin within 8 hours

Methodology
Electrochemiluminescence Immunoassay (ECLIA)

Setup Schedule

Mon-sat

Report Available

2-6 days

Reference Range

	Male (ng/mL)	Female (ng/mL)
0-4 Years	Not established	Not established
5-9 Years	47-142	47-142
10-13 Years	49-167	49-167
14-17 Years	26-203	14-85
>17 Years	9-38	8-32

Clinical Significance

Osteocalcin, the most abundant non-collagen protein in bone matrix, is a bone-specific, calcium binding protein. Serum osteocalcin levels are related to the rate of bone turnover in various disorders of bone metabolism, e.g., osteoporosis, primary and secondary hyperparathyroidism, and Paget's disease.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.