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Phospholipase A2 Receptor (PLA2R) Antibody Panel
Test Code93875
Alias/See Also
LAB00457
PLA2R
POSPHOLIPASE A2 RECEPTOR ANTIBODIES
PLA2R
POSPHOLIPASE A2 RECEPTOR ANTIBODIES
CPT Codes
83520, 86255
Includes
Phospholipase A2 Receptor (PLA2R) Antibody, ELISA
Phospholipase A2 Receptor (PLA2R) Antibody, IFA
Phospholipase A2 Receptor (PLA2R) Antibody, IFA
Preferred Specimen
1.5 mL serum
Minimum Volume
1 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Methodology
Enzyme Linked Immunosorbent Assay (ELISA) • Immunofluorescence Assay (IFA)
Reference Range
Phospholipase A2 Receptor (PLA2R) Ab, ELISA
RU/mL | |
<14 | Negative |
14-19 | Borderline |
>19 | Positive |
Phospholipase A2 Receptor (PLA2R) Ab, IFA | Negative |
Clinical Significance
Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.