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FGF 23 (Fibroblast Growth Factor 23)
Test Code91931
Alias/See Also
LAB01064
CPT Codes
83520
Preferred Specimen
1 mL frozen plasma collected in an EDTA (lavender-top) tube
Patient Preparation
Fasting specimen is preferred
Minimum Volume
0.3 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 6 hours
Frozen: 90 days
Refrigerated: 6 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
ELISA
FDA Status
The performance characteristics of this test were determined by Pan Laboratories, Irvine, CA. It has not been cleared or approved by the U.S. Food and Drug Administration.
Setup Schedule
Fri
Report Available
2-9 days
Reference Range
Adults | <180 RU /mL |
Children (1 month-17 years) | <230 RU /mL |
Infants | >900 RU /mL |
Clinical Significance
FGF 23 is a major regulator of phosphate homeostasis. It is mainly produced in bone and also in the thymus and brain. Intact FGF 23 is biologically active. High serum FGF 23 levels stimulate FGF 23 expression. It interacts with a specific receptor in renal tubular cells, decreasing the expression of type IIa sodium/phosphate cotransponders and resulting in decreased phosphate reabsorption. FGF reduces the formation of 1, 25 dihydroxy vitamin D resulting in reduced phosphate reabsorption. When FGF 23 levels are pathologically elevated with normal renal function, hypophosphatemia with or without osteomalacia occurs. Measurement of serum FGF 23 can assist in the diagnosis and management of disorders of phosphate and bone metabolism. Human FGF 23 measurement can provide an important diagnostic tool for the laboratory evaluation of patients with a variety of hypo and hyperphosphatemic disorders.
Performing Laboratory
Pan Laboratories |
15375 Barranca Parkway, E-101 |
Irvine, CA 92618-2217 |