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Mycophenolic Acid, LC/MS/MS
Test Code10662
CPT Codes
80180<br><strong>This test is not available for New York patient testing at med fusion-Lewisville, TX.</strong><br><strong>Orders for New York patients will be redirected to Quest Diagnostics Nichols Institute-Chantilly, VA for testing.</strong>
Includes
Mycophenolic Acid and MPA Glucuronide
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Patient Preparation
Optimum time to collect sample: 0.5 to 1 hour before next dose (trough) at steady-state (3-5 days after treatment with oral doses).
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: Sodium heparin (green-top) tube or EDTA (lavender-top) tube
Instructions
Serum: Collect blood in a red-top tube (no gel). Allow blood to clot at 15-28° C for 20-30 minutes. Centrifuge at 25-28° C (2200-2500 rpm, 1000 x g) for 8-10 minutes. Transfer serum to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Plasma: Draw blood into an EDTA (lavender-top) tube. Separate cells by centrifugation at 18-25° C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Plasma: Draw blood into an EDTA (lavender-top) tube. Separate cells by centrifugation at 18-25° C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 60 days
Refrigerated: 14 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Improperly labeled specimens • Specimens left at room temperature >72 hours • Gel barrier/serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
This test is not available for New York patient testing at med fusion-Lewisville, TX.
Orders for New York patients will be redirected to Quest Diagnostics Nichols Institute-Chantilly, VA for testing.
Setup Schedule
Mon-Sat
Report Available
4-5 days
Reference Range
Mycophenolic Acid | 1.0-3.5 mcg/mL |
MPA Glucuronide | 35.0-100.0 mcg/mL |
Clinical Significance
Mycophenolic acid is an immunosuppressant used in tissue transplants. It prevents graft rejection by the host's immune system. It is very important to monitor its level. Too little of this drug will cause graft rejection, while too much will lead to infection. Monitoring its level is essential to optimize therapeutic effects, avoid toxicity, and assure compliance.
Performing Laboratory
med fusion |
2501 South State Hwy 121, Suite 1100 |
Lewisville, TX 75067-8188 |