Metanephrines, Fractionated, LC/MS/MS, 24-Hour Urine

Test Code

14962

Alias/See Also

LAB409

CPT Codes
83835

Includes

Metanephrine, Normetanephrine, Total Metanephrines

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

5 mL 24-hour urine with 25 mL 6N HCl collected in a 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.

Minimum Volume

1.5 mL

Other Acceptable Specimens

Frozen 24-hour preserved urine or unpreserved urine

Instructions

After urine collection, add 25 mL 6N HCL to maintain a pH below 3. Urine without preservative is accecptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume and patient's age on test requisition and urine vial.

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Preserved urine
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 90 days

Unpreserved urine
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Urine collected with boric acid

Methodology
Chromatography/Tandem Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Mon-sat

Report Available

3-6 days

Reference Range

See Laboratory Report

Clinical Significance

Test is useful in the evaluation of pheochromocytoma.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.