A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Actin (Smooth Muscle) Antibody (IgG)
Test Code15043
Alias/See Also
LAB826
CPT Codes
86015
Preferred Specimen
0.5 mL serum
Minimum Volume
0.25 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Setup Schedule
Tues-Sat
Report Available
3-5 days
Reference Range
<20 U | Negative |
≥20 U |
Positive |
Antibodies recognizing actin are the main component of smooth muscle antibodies associated with autoimmune liver disease. Actin antibodies are found in approximately 75% of patients with autoimmune hepatitis (AIH) type 1, approximately 65% of patients with autoimmune cholangitis, approximately 30% of patients with primary biliary cirrhosis, and approximately 2% of healthy people. High values are closely correlated with AIH type 1.
Clinical Significance
Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |