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D-Lactate, Plasma
Test Code15516
CPT Codes
83605
Preferred Specimen
0.5 mL plasma collected in a potassium oxalate/sodium fluoride (gray-top) tube
Minimum Volume
0.15 mL
Other Acceptable Specimens
Plasma collected in: Sodium heparin (green-top) tube
Instructions
Centrifuge, aliquot plasma into plastic vial, and freeze immediately.
Note: If collecting in a sodium heparin tube, centrifugation must occur within one hour.
Note: If collecting in a sodium heparin tube, centrifugation must occur within one hour.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 91 days
Refrigerated: 91 days
Frozen: 91 days
Refrigerated: 91 days
Frozen: 91 days
Methodology
Gas Chromatography/Mass Spectrometry (GC/MS) • Stable Isotope Dilution Analysis
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Setup Schedule
Mon, thurs
Report Available
4-8 days
Reference Range
See Laboratory Report
Clinical Significance
D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. When large amounts of D-lactate are present, individuals can experience metabolic acidosis, altered mental status (from drowsiness to coma), and a variety of other neurologic symptoms, particularly dysarthria and ataxia.
D-lactate acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or, following a jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the critical presentation of D-lactic acidosis.
Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, DLAC/D-Lactate, Plasma). However, as D-lactate is readily excreted in urine, DLAU/D-Lactate, Urine is the preferred specimen for D-lactate determinations.
D-lactate acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or, following a jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the critical presentation of D-lactic acidosis.
Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, DLAC/D-Lactate, Plasma). However, as D-lactate is readily excreted in urine, DLAU/D-Lactate, Urine is the preferred specimen for D-lactate determinations.
Performing Laboratory
| Mayo Clinical Laboratories |
| 200 1st Street SW |
| Rochester, MN 55905-0001 |