| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
IGF-1, LC/MS
Test Code16293
Alias/See Also
LAB526
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)
CPT Codes
84305
Preferred Specimen
0.5 mL serum
Minimum Volume
0.3 mL
Instructions
Collect blood in a red-top tube (no gel) or serum separator tube (SST).
For red-top tube (no gel), allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.
For red-top tube (no gel), allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 60 days
Refrigerated: 7 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate hemolysis • Grossly lipemic • Received in glass tube • Received room temperature • Grossly icteric
Methodology
Liquid Chromatography/Mass Spectrometry (LC/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Daily
Report Available
1-4 days
Reference Range
| Pediatric | Male (ng/mL) | Female (ng/mL) |
| <1 Years | 14-142 | 17-185 |
| 1-1.9 Years | 12-134 | 15-175 |
| 2-2.9 Years | 12-135 | 16-179 |
| 3-3.9 Years | 30-155 | 38-214 |
| 4-4.9 Years | 28-181 | 34-238 |
| 5-5.9 Years | 31-214 | 37-272 |
| 6-6.9 Years | 38-253 | 45-316 |
| 7-7.9 Years | 48-298 | 58-367 |
| 8-8.9 Years | 62-347 | 76-424 |
| 9-9.9 Years | 80-398 | 99-483 |
| 10-10.9 Years | 100-449 | 125-541 |
| 11-11.9 Years | 123-497 | 152-593 |
| 12-12.9 Years | 146-541 | 178-636 |
| 13-13.9 Years | 168-576 | 200-664 |
| 14-14.9 Years | 187-599 | 214-673 |
| 15-15.9 Years | 201-609 | 218-659 |
| 16-16.9 Years | 209-602 | 208-619 |
| 17-17.9 Years | 207-576 | 185-551 |
| Adult | (ng/mL) |
| 18-19.9 Years | 108-548 |
| 20-24.9 Years | 83-456 |
| 25-29.9 Years | 63-373 |
| 30-39.9 Years | 53-331 |
| 40-49.9 Years | 52-328 |
| 50-59.9 Years | 50-317 |
| 60-69.9 Years | 41-279 |
| 70-79.9 Years | 34-245 |
| >80 Years | 34-246 |
| Z-Score (Male) | -2.0 - +2.0 SD |
| Z-Score (Female) | -2.0 - +2.0 SD |
| Pediatric Tanner Stages | See Laboratory Report |
Clinical Significance
Insulin-like Growth Factor 1 (IGF-1, or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (Hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (Hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |