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Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
Test Code16845
Alias/See Also
LAB00969
CPT Codes
82088, 84244
Includes
Aldosterone, LC/MS and Plasma Renin Activity, LC/MS/MS
Preferred Specimen
1.8 mL frozen plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.8 mL
Instructions
Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days
Refrigerated: 24 hours
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate to gross hemolysis • Plasma collected in a plasma separator tube • Received thawed
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
Aldosterone
| Adult | |
| Upright 8:00-10:00 A.M. | ≤28 ng/dL |
| Upright 4:00-6:00 P.M. | ≤21 ng/dL |
| Supine 8:00-10:00 A.M. | 3-16 ng/dL |
| Pediatric | |
| 1-12 Months | 2-70 ng/dL |
| 1-4 Years | 2-37 ng/dL |
| 5-9 Years | ≤9 ng/dL |
| 10-13 Years | ≤21 ng/dL |
| 14-17 Years | ≤35 ng/dL |
| Infants | |
| Premature (31-35 Weeks) | ≤144 ng/dL |
| Term | ≤217 ng/dL |
| Tanner Stages | |
| II-III Males | 1-13 ng/dL |
| II-III Females | 2-20 ng/dL |
| IV-V Males | 3-14 ng/dL |
| IV-V Females | 4-32 ng/dL |
| Plasma Renin Activity | 0.25-5.82 ng/mL/h |
| Aldosterone/PRA Ratio | 0.9-28.9 Ratio |
Clinical Significance
The Aldosterone-renin ratio is used to screen for primary aldosteronism.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |