Adenosine Deaminase, Pleural Fluid

Test Code
17696


Alias/See Also
LAB00479


CPT Codes
84311

Preferred Specimen
0.5 mL pleural fluid


Transport Container
Sterile plastic leak-proof container


Transport Temperature
Frozen


Specimen Stability
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 6 months


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature


Methodology
Kinetic Spectrophotometric (KS)

FDA Status
This test was performed using a kit that has ot been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Setup Schedule
Mon-sat


Reference Range
Adenosine Deaminase, Pleural Fluid <9.2 U/L
  Tuberculosis mean 92.1 U/L
  Metastatic malignancies mean 23.3 U/L
  Mesotheliomas mean 34.9 U/L
  Pulmonary embolism mean 23.8 U/L
  Lymphoma mean 64.3 U/L


Clinical Significance
An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Additional disease states that may result in elevated AD activity include liver cirrhosis, liver fibrosis, certain malignancies (e. g. lymphoma), viral hepatitis, and autoimmune diseases (e. g. SLE,  rheumatoid arthritis).


Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA
14225 Newbrook Drive
Chantilly, VA 20151-2228




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.