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Aldosterone, 24-Hour Urine
Test Code229
Alias/See Also
LAB354
CPT Codes
82088, 82570
Includes
Creatinine
CPT code 81050 may be added at an additional charge for volume measurement
CPT code 81050 may be added at an additional charge for volume measurement
Preferred Specimen
5 mL 24-hour urine collected in a 24-hour urine container
Minimum Volume
0.5 mL
Other Acceptable Specimens
24-hour urine collected in a 10 g boric acid container or random urine (reference ranges do not apply) collected in a no preservative container
Instructions
Record 24-hour urine volume on test requisition and urine vial. Refrigerate during and after collection.
Reference ranges do not apply to random urine samples.
Reference ranges do not apply to random urine samples.
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 28 days
Frozen: 21 days
Refrigerated: 28 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Urine collected with HCl
Methodology
Hydrolysis • Extraction • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Tues, sun
Report Available
3-9 days
Reference Range
Aldosterone, 24-Hour Urine
Random Sodium Diet
Oral sodium loading test (high salt diet for 3 days): 12 mcg/24 hrs or less*
*Funder JW, Carey RM, Mantero F, et al. The Management of Primary
Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016; 101:1889-1916
Creatinine, 24-Hour Urine
Random Sodium Diet
| Age | mcg/24 hours |
| 2-7 years | 5.7 or less |
| 8-11 years | 10.2 or less |
| 12-16 years | 15.6 or less |
| Adults | 2.3-21.0 |
*Funder JW, Carey RM, Mantero F, et al. The Management of Primary
Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016; 101:1889-1916
Creatinine, 24-Hour Urine
| <3 Years | Not established |
| 3-8 Years | 0.10-0.80 g/24 h |
| 9-12 Years | 0.20-1.40 g/24 h |
| 13-17 Years | 0.40-1.90 g/24 h |
| >17 Years | 0.50-2.15 g/24 h |
Clinical Significance
Aldosterone is a hormone produced by the adrenal glands. Patients with primary hyperaldosteronism exhibit hypokalemia, hypertension, and low direct renin concentrations.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |