Heparin, Anti-Xa

Message
*Take to processing ASAP.


Test Code
30292


Alias/See Also
LAB317


CPT Codes
85520

Preferred Specimen
2 mL frozen plasma collected in 3.2% sodium citrate (light blue-top) tube 


Minimum Volume
1 mL


Instructions
Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/uL). Freeze immediately and ship on dry ice.


Transport Container
Transport tube


Transport Temperature
Frozen


Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis


Methodology
Chromogenic Assay

Setup Schedule
Mon-fri, sun


Report Available
2-3 days


Reference Range
UFH Therapeutic Range 0.30-0.70 IU/mL

LMWH Therapeutic Ranges (target anti-Xa levels measured 4 hours after dosing):
Enoxaparin (Lovenox)  
  Therapeutic bid dosing 0.6-1.0 IU/mL
  Therapeutic qD dosing >1.0 IU/mL
Tinzaparin (Innohep)  
  Therapeutic qD 0.85 IU/mL
Dalteparin (Fragmin)  
  Therapeutic qD 1.05 IU/mL

For more information on this test, go to: http://education.questdiagnostics.com/faq/FAQ53v1 (This link is being provided for informational/ educational purposes only.)


Clinical Significance
This assay is useful in measuring heparin concentration in patients treated with low molecular weight heparins (i.e. Enoxaparin/Lovenox) or unfractionated heparin. It is not intended for measurement of Rivaroxaban (Xarelto) or Fondaparinux (Arixtra).
Refer to test code 90981 for Rivaroxaban measurement and test code 16103 for Fondaparinux measurement.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.