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Factor V Activity, Clotting
MessageTest Code
Alias/See Also
CPT Codes
85220
Preferred Specimen
Minimum Volume
Instructions
Transport Container
Transport Temperature
Frozen
Specimen Stability
Refrigerated: Unacceptable
Frozen -20° C: 14 days
Frozen -70° C: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Photometric Clot Detection
Setup Schedule
Report Available
Limitations
Reference Range
Clinical Significance
This test measures coagulation factor V activity and may be used to help determine the cause of a prolonged prothrombin time (PT) or activated partial thromboplastin time (aPTT).
Coagulation factor V plays an essential role in hemostasis by promoting thrombin generation at the activated platelet surface. Deficiency of factor V leads to a rare bleeding disorder and can be congenital or acquired. Congenital factor V deficiency, also known as parahemophilia or Owren's disease, has an incidence of 1 per one million [1] and is caused by pathogenic variants of the F5 gene, which encodes factor V. Acquired factor V deficiency can be caused by liver disease, consumptive coagulopathies, disseminated intravascular coagulation, or inhibitors (autoantibodies or alloantibodies) that interfere with factor V activity. Inhibitors to factor V may be induced by chemical agents, drugs, or surgical procedures using bovine thrombin [1].
Factor activity assays, including factor V activity assay, are usually indicated in patients with bleeding symptoms and prolonged PT and aPTT [1].
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
Reference
1. Tabibian S, et al. Semin Thromb Hemost. 2019;45(5):523-543.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |