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Cocaine and Metabolites, Confirmation, Serum
Test Code35818
Alias/See Also
LAB968
COC
COCAETHYLENE
M-HYDROXYBENZOYLECGONINE
COC
COCAETHYLENE
M-HYDROXYBENZOYLECGONINE
Preferred Specimen
5 mL serum collected in a red-top tube (no gel)
Minimum Volume
2.5 mL
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen: 7 days
Refrigerated: 72 hours
Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Chromatography Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
10: 00 a. M. Tues, sat
Report Available
1-4 days
Clinical Significance
Cocaine is metabolized mainly to benzoylecgonine and ecgonine methylester. Cocaethylene is an indication of concurrent cocaine and alcohol consumption. Serum half-life of cocaine is 1-5 hours. Benzoylecgonine appears in circulation 15-30 minutes after cocaine administration. Elimination half-life of benzoylecgonine is 5-6 hours. Benzoylecgonine will be detectable in urine after 2-3 hours and urine remains positive for 2-3 days (longer for chronic abusers) after cocaine use.
Performing Laboratory
Quest Diagnostics Nichols Institute-Valencia |
8407 Fallbrook Ave, Suite 100 |
West Hills, CA 91304-3226 |