Sirolimus, LC/MS/MS

Message
WHOLE BLOOD - DO NOT CENTRIFUGE


Test Code
36712


Alias/See Also
LAB875
RAPAMYCIN
RAPAMUNE


CPT Codes
80195<br><strong>This test is not available for New York patient testing at med fusion-Lewisville, TX.</strong><br><strong>Orders for New York patients will be redirected to Quest Diagnostics Nichols Institute-Chantilly, VA for testing.</strong>

Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube


Patient Preparation
Collect specimen 1 hour prior to next dose (12 hour trough)

Minimum Volume
1 mL


Transport Container
EDTA (lavender-top) tube


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen


Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test is not available for New York patient testing at med fusion-Lewisville, TX.
Orders for New York patients will be redirected to Quest Diagnostics Nichols Institute-Chantilly, VA for testing.

Setup Schedule
Mon-Sat


Report Available
2-4 days


Reference Range
3.0-18.0 ng/mL


Clinical Significance
Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.


Performing Laboratory
med fusion
2501 South State Hwy 121, Suite 1100
Lewisville, TX 75067-8188




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.