Sirolimus, LC/MS/MS

Message

WHOLE BLOOD - DO NOT CENTRIFUGE

Test Code

36712

Alias/See Also

LAB875
RAPAMYCIN
RAPAMUNE

CPT Codes
80195

Preferred Specimen

2 mL whole blood collected in an EDTA (lavender-top) tube

Patient Preparation
Collect specimen 1 hour prior to next dose (12 hour trough)

Minimum Volume

1 mL

Transport Container

EDTA (lavender-top) tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted whole blood

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

10: 00 a. M. Mon-sat

Report Available

1-2 days

Reference Range

3.0-18.0 ng/mL

Clinical Significance

Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Performing Laboratory

Quest Diagnostics Nichols Institute

27027 Tourney Road

Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.