Histone Antibodies

Test Code
37056


Alias/See Also
LAB00209


CPT Codes
83516

Preferred Specimen
1 mL serum


Patient Preparation
Overnight fasting preferred

Minimum Volume
0.3 mL


Transport Container
Transport tube


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 24 hours
Refrigerated: 14 days
Frozen: 30 days


Methodology
Enzyme Immunoassay (EIA)

Setup Schedule
Tues, Thurs, Sat


Report Available
3-6 days


Reference Range
Value Explanation of Results
<1.0 Negative
1.0-1.5 Weak Positive
1.6-2.5 Moderate Positive
>2.5 Strong Positive


Clinical Significance
Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.