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Heparin-Induced Platelet Antibody
Test Code414
Alias/See Also
LAB766
CPT Codes
86022
Preferred Specimen
1 mL frozen serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: 3.2% sodium citrate (light blue-top) tube
Instructions
Serum (preferred): Centrifuge red top tube 15 minutes at approximately 1500 g as soon as possible after clotting.
Plasma (acceptable): Centrifuge blue top tube 20 minutes at approximately 2500 g. Remove plasma from the cells as soon as possible.
Plasma (acceptable): Centrifuge blue top tube 20 minutes at approximately 2500 g. Remove plasma from the cells as soon as possible.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Rrefrigerated: Unacceptable
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Received room temperature • Received refrigerated • Icteric • Serum separator tube (SST)
Methodology
Immunoassay (IA)
Setup Schedule
Daily
Report Available
1 day
Limitations
When heparin is stopped, antibody that may have been present disappears within weeks to months.
Reference Range
| Heparin-Induced Platelet Antibody | Negative |
| Patient O.D. | ≤0.300 OD Units |
Clinical Significance
Heparin can induce thrombocytopenia, a decreased platelet count, due to antibody stimulation. False positive results may be due to immune complexes. False negative results may be due to low titer, low avidity antibodies.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |