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Myeloperoxidase Antibody (MPO)
Test Code8796
Alias/See Also
LAB00251
CPT Codes
86021
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Immunoassay (IA)
Setup Schedule
Mon-sat
Report Available
1-2 days
Limitations
Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.
Reference Range
<1.0 AI | No antibody detected |
≥1.0 AI | Antibody detected |
Clinical Significance
Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |