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Sensory-Motor Neuropathy Antibody Panel (Ganglioside)
Test Code90129
Alias/See Also
LAB00308
SMN AB PNL
GANGLIOSIDE
SMN AB PNL
GANGLIOSIDE
CPT Codes
83520 (x9)
Includes
Ganglioside GM-1 Antibodies (IgG, IgM), EIA
Ganglioside GD1a Antibody (IgG, IgM), EIA
Ganglioside GD1b Antibody (IgG, IgM), EIA
Ganglioside GQ1b Antibody (IgG), EIA
Ganglioside Asialo-GM-1 Antibody (IgG, IgM), EIA
Ganglioside GD1a Antibody (IgG, IgM), EIA
Ganglioside GD1b Antibody (IgG, IgM), EIA
Ganglioside GQ1b Antibody (IgG), EIA
Ganglioside Asialo-GM-1 Antibody (IgG, IgM), EIA
Preferred Specimen
3 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1.6 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunoassay (IA)
Reference Range
See Laboratory Report
Clinical Significance
The presence of antibodies to the gangliosides GM1, Asialo-GM1, GD1a and GD1b has been associated with motor and sensorimotor neuropathies. High titers of antibody to GM1 are most typical of multifocal motor neuropathy; however, antibodies to other gangliosides are often present. In most cases of chronic immune neuropathies, anti-ganglioside antibodies are IgM class. IgG antibodies have been reported less often, generally associated with acute conditions. Many reports have found increased anti-asialo-GM1 antibody titers in patients with multifocal motor neuropathy, lower motor neuron disease, sensorimotor neuropathy, or motor neuropathy with or without multifocal block, Guillain-Barré Syndrome, and amyotrophic lateral sclerosis. There may be a relationship between titers of asialo-GM1 antibodies and clinical status in individual patients. In some lower motor neuron disorders, improvement in strength has occurred after therapeutic reduction in anti-asialo-GM1 antibody titers. Polyclonal GQ1b IgG antibody can serve as an aid in the diagnosis of acute ataxia neuropathy with ophthalmoplegia or of Miller-Fisher Syndrome.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |