Diazepam and Metabolite

Test Code

90853

Alias/See Also

LAB468
VALIUM

CPT Codes
80299

Includes

Diazepam, Nordiazepam, Diazepam and Nordiazepam

Preferred Specimen

2 mL serum collected in a red-top tube (no gel)

Patient Preparation
Collect at trough concentration, i.e., immediately before the administration of the next dose

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST) • Received room temperature

Methodology
Calculation (CALC) • Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

10: 00 a. M. Tues, thurs, sat

Report Available

2-4 days

Reference Range

Diazepam	See Laboratory Report
Nordiazepam	See Laboratory Report

Diazepam and Nordiazepam

Therapeutic	100-1500 ng/mL
Potentially toxic	>3000 ng/mL

Clinical Significance

Therapeutic drug monitoring of anxiolytic drug. Nordiazepam is the active metabolite of the parent drug. Elimination half-life is 20-90 hours.

Performing Laboratory

Quest Diagnostics Nichols Institute

27027 Tourney Road

Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.