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Diazepam and Metabolite
Test Code90853
Alias/See Also
LAB468
VALIUM
VALIUM
CPT Codes
80299
Includes
Diazepam, Nordiazepam, Diazepam and Nordiazepam
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Patient Preparation
Collect at trough concentration, i.e., immediately before the administration of the next dose
Minimum Volume
1 mL
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days
Refrigerated: 5 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST) • Received room temperature
Methodology
Calculation (CALC) • Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
10: 00 a. M. Tues, thurs, sat
Report Available
2-4 days
Reference Range
Diazepam | See Laboratory Report |
Nordiazepam | See Laboratory Report |
Diazepam and Nordiazepam
Therapeutic | 100-1500 ng/mL |
Potentially toxic | >3000 ng/mL |
Clinical Significance
Therapeutic drug monitoring of anxiolytic drug. Nordiazepam is the active metabolite of the parent drug. Elimination half-life is 20-90 hours.
Performing Laboratory
Quest Diagnostics Nichols Institute-Valencia |
8407 Fallbrook Ave, Suite 100 |
West Hills, CA 91304-3226 |