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Vitamin B3
MessagePROTECT FROM LIGHT.
POUR SERUM/PLASMA INTO AMBER TRANSPORT TUBE (PREFERRED) OR TRANSPORT TUBE WRAPPED IN ALUMINUM FOIL TO PROTECT FROM LIGHT.
POUR SERUM/PLASMA INTO AMBER TRANSPORT TUBE (PREFERRED) OR TRANSPORT TUBE WRAPPED IN ALUMINUM FOIL TO PROTECT FROM LIGHT.
Test Code
91029
Alias/See Also
LAB1109
VIT B3
NICOTINIC ACID
NICOTINAMIDE
VIT B3
NICOTINIC ACID
NICOTINAMIDE
CPT Codes
84591
Includes
Nicotinamide and Nicotinic Acid
Preferred Specimen
1 mL frozen serum collected in a red-top tube (no gel) - protected from light
Minimum Volume
0.5 mL
Other Acceptable Specimens
Frozen plasma collected in an EDTA (lavender-top) tube protected from light
Pour plasma into amber transport tube (preferred) or transport tube wrapped in aluminum foil to protect from light.
Pour plasma into amber transport tube (preferred) or transport tube wrapped in aluminum foil to protect from light.
Instructions
Pour serum into amber transport tube (preferred) or transport tube wrapped in aluminum foil to protect from light.
Transport Container
Amber transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
10: 00 a. M. Tues, thurs, sat
Report Available
2-4 days
Reference Range
Nicotinamide
Nicotinamide is a metabolite of nicotinic acid. Due to the large variability in the metabolism of nicotinic acid, plasma concentrations of this metabolite are variable. In one study, fasting plasma concentrations were reported to be approximately 40 ng/mL. In another study it was reported that the administration of a single 1000 mg of extended-release tablet of nicotinic acid resulted in a mean peak nicotinamide concentration of 400 ng/mL between 5 and 10 hours post dose, decreasing to about 100 ng/mL by 16 hours post dose.
Nicotinic Acid
Due to the large variability in the metabolism of nicotinic acid, the dosing preparation used (immediate-release vs. extended release), and the mg doses used, the serum concentrations may range from less than 20 ng/mL to about 30,000 ng/mL. After oral administration of an immediate-release tablet, peak plasma concentrations occur in 4 to 5 hours. The plasma half-life of nicotinic acid is about one hour. In one study, fasting plasma concentrations were reported to be less than 20 ng/mL. In another study, it was reported that the administration of a single 1000 mg extended-release tablet resulted in mean nicotinic acid concentrations of less than 50 ng/mL.
Nicotinamide is a metabolite of nicotinic acid. Due to the large variability in the metabolism of nicotinic acid, plasma concentrations of this metabolite are variable. In one study, fasting plasma concentrations were reported to be approximately 40 ng/mL. In another study it was reported that the administration of a single 1000 mg of extended-release tablet of nicotinic acid resulted in a mean peak nicotinamide concentration of 400 ng/mL between 5 and 10 hours post dose, decreasing to about 100 ng/mL by 16 hours post dose.
Nicotinic Acid
Due to the large variability in the metabolism of nicotinic acid, the dosing preparation used (immediate-release vs. extended release), and the mg doses used, the serum concentrations may range from less than 20 ng/mL to about 30,000 ng/mL. After oral administration of an immediate-release tablet, peak plasma concentrations occur in 4 to 5 hours. The plasma half-life of nicotinic acid is about one hour. In one study, fasting plasma concentrations were reported to be less than 20 ng/mL. In another study, it was reported that the administration of a single 1000 mg extended-release tablet resulted in mean nicotinic acid concentrations of less than 50 ng/mL.
Clinical Significance
Nicotinic acid occurs naturally in plants and animals and is also added to many foods as a vitamin supplement.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 27027 Tourney Road |
| Valencia, CA 91355-5386 |