VMA (Vanillylmandelic Acid), 24-Hour Urine without Creatinine

Test Code

CPT Codes

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen
10 mL aliquot from a 24-hour urine that has been preserved with 25 mL 6N HCl, collected in a plastic, 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. However common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco (including use of nicotine patch), bananas, citrus fruits and strenuous exercise prior to collection.

Minimum Volume
5 mL

Other Acceptable Specimens
Aliquot from a 24-hour urine, unpreserved, with a pH ≤6, collected in a plastic, 24-hour urine container

Transport Container
Plastic urine container

Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen

Specimen Stability
⁠⁠⁠⁠⁠⁠⁠Preserved urine
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 1 year

Unpreserved urine
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6

High Performance Liquid Chromatography (HPLC) • Electrochemical Detection

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Report Available
Report available: 2-6 days

Reference Range
<3 YearsNot established
3-8 Years≤2.3 mg/24 h
9-12 Years≤3.4 mg/24 h
13-17 Years   ≤3.9 mg/24 h
Adult≤6.0 mg/24 h

Clinical Significance
Vanillylmandelic Acid (VMA) is the major urinary project resulting from the metabolic degradation of catecholamine, norepinephrine and epinephrine. Elevated concentrations of VMA are commonly found in cases of catecholamine secreting tumors such as pheochromocytoma, neuroblastoma, and ganglioneuroma.
Drugs which can interfere with testing due to physiologic response: clonidine, L-dopa, methocarbamol, monoamine oxidase inhibitors, reserpine, salicylates.

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.