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Voltage-Gated Potassium Channel (VGKC) Antibody
Test Code93883
Alias/See Also
LAB00318
VGKC
VGKC
CPT Codes
83519
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 48 hours
Refrigerated: 48 hours
Frozen: 73 days
Refrigerated: 48 hours
Frozen: 73 days
Methodology
Radioimmunoassay (RIA)
Setup Schedule
Mon, wed
Report Available
7-14 days
Reference Range
<80 pmol/L
Clinical Significance
Limbic encephalitis (LE) is a paraneoplastic neurological syndrome often associated with small cell lung carcinoma and more rarely with testicular, breast, and other tumors. Clinical hallmarks of paraneoplastic limbic encephalitis are changing mental status, short-term memory impairment, seizures, confusion, and behavioral changes. Hu antibody-negative LE patients usually do not develop symptoms beyond the limbic system and appear to improve more often after treatment of the cancer than those who have Hu antibodies, suggesting that the pathogenesis of the LE in both groups could be different. Recent studies have detected antibodies to voltage-gated potassium channels (VGKC) in patients with LE, with and without associated tumors. Neurological symptoms were found to improve with a reduction of VGKC antibody levels.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |