Lp-PLA2 Activity

Test Code

94267

Alias/See Also

LAB1045
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (Lp-LPA2)

CPT Codes
83698

Preferred Specimen

1 mL serum

Patient Preparation
Fasting preferred, but not required

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube

Instructions

Process samples by removing or separating serum from red blood cells using standard separation procedures. Recommend to centrifuge and separate samples with four hours of venipuncture as per good laboratory practices.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 28 days
Refrigerated: 28 days
Frozen: 90 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric

Methodology
Enzymatic Assay (EZA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Mon-sat

Report Available

3-6 days

Reference Range

≤123 nmol/min/mL

Risk

Optimal	≤123 nmol/min/mL
High	>123 nmol/min/mL

Clinical Significance

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.