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Lp-PLA2 Activity
Test Code94267
Alias/See Also
LAB1045
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (Lp-LPA2)
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (Lp-LPA2)
CPT Codes
83698
Preferred Specimen
1 mL serum
Patient Preparation
Fasting preferred, but not required
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Instructions
Process samples by removing or separating serum from red blood cells using standard separation procedures. Recommend to centrifuge and separate samples with four hours of venipuncture as per good laboratory practices.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 28 days
Refrigerated: 28 days
Frozen: 90 days
Refrigerated: 28 days
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric
Methodology
Enzymatic Assay (EZA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Mon-sat
Report Available
3-6 days
Reference Range
≤123 nmol/min/mL
Risk
Risk
Optimal | ≤123 nmol/min/mL |
High | >123 nmol/min/mL |
Clinical Significance
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |