Beta-Amyloid 42/40 Ratio and Apolipoprotein E (APOE) Isoform Panel, CSF

Test Code

94628

Alias/See Also

LAB00380

CPT Codes
82233, 82234, 82172

Preferred Specimen

1.6 mL CSF

Minimum Volume

0.8 mL

Instructions

Collect and transport CSF in a polypropylene tube. Store frozen.

Note: Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended.

Transport Container

Polypropylene tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 72 hours
Refrigerated: 5 days
Frozen: 31 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemic • Specimen collected in a glass, polystyrene, or polycarbonate tube • Icteric

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics . It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Sun

Report Available

5-12 days

Reference Range

See Laboratory Report

Clinical Significance

This panel of LC/MS/MS assays measures Beta-Amyloid 42/40 Ratio and ApoE Isoform and Total ApoE in CSF. Test results are further analyzed by an algorithm that calculates a risk assessment score. Based on this score, patients are categorized as low, intermediate, or high risk of having AD.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.