PORPHOBILINOGEN DEAMINASE (PBGD), WHOLE BLOOD

Message

THIS TEST REQUIRES A WILD CODE FROM QUEST.
Call Carrie x4171 or Amber x4173

Test Code

LAB00878

Alias/See Also

LAB00878

CPT Codes
82657

Physician Attestation of Informed Consent

http://www.mayocliniclabs.com/it-mmfiles/Informed_Consent_for_Genetic_Testing.pdf

Preferred Specimen

4.0 mL Dark Green Top (Sodium Heparin) - Whole Blood

Patient Preparation
Abstinence from alcohol for at least 24 hours prior to specmimen collection is essential as ethanol includes prophobilinogen deaminase activity, which may lead to a false-normal result.

Minimum Volume

3.0 mL Dark Green Top (Sodium Heparin) - Whole Blood

Other Acceptable Specimens

Lavender (EDTA)

Instructions

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 8 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis

Methodology
Enzymatic End Point/Spectrofluorometric

Report Available

3-9 days

Limitations

A normal result does not rule-out acute intermittent porphyria; 5% to 10% of affected individuals will have normal erythrocyte porphobilinogen deaminase activity. Additionally, enzyme activity may be increased during an acute attack; therefore, the enzyme level should be assessed when the patient is asymptomatic.

Reference Range

Porphobilinogen Deaminase:
> or = 7.0 nmol/L/sec
6.0-6.9 nmol/L/sec (indeterminate)
<6.0 nmol/L/sec (deminished)

Clinical Significance

Confirmation of a diagnosis of acute intermittent porphyria.

Performing Laboratory
Mayo Clinic Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.