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PORPHOBILINOGEN DEAMINASE (PBGD), WHOLE BLOOD
MessageTHIS TEST REQUIRES A WILD CODE FROM QUEST.
Call Carrie x4171 or Amber x4173
Call Carrie x4171 or Amber x4173
Test Code
LAB00878
Alias/See Also
LAB00878
CPT Codes
82657
Physician Attestation of Informed Consent
Preferred Specimen
4.0 mL Dark Green Top (Sodium Heparin) - Whole Blood
Patient Preparation
Abstinence from alcohol for at least 24 hours prior to specmimen collection is essential as ethanol includes prophobilinogen deaminase activity, which may lead to a false-normal result.
Minimum Volume
3.0 mL Dark Green Top (Sodium Heparin) - Whole Blood
Other Acceptable Specimens
Lavender (EDTA)
Instructions
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 8 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Enzymatic End Point/Spectrofluorometric
Report Available
3-9 days
Limitations
A normal result does not rule-out acute intermittent porphyria; 5% to 10% of affected individuals will have normal erythrocyte porphobilinogen deaminase activity. Additionally, enzyme activity may be increased during an acute attack; therefore, the enzyme level should be assessed when the patient is asymptomatic.
Reference Range
Porphobilinogen Deaminase:
> or = 7.0 nmol/L/sec
6.0-6.9 nmol/L/sec (indeterminate)
<6.0 nmol/L/sec (deminished)
> or = 7.0 nmol/L/sec
6.0-6.9 nmol/L/sec (indeterminate)
<6.0 nmol/L/sec (deminished)
Clinical Significance
Confirmation of a diagnosis of acute intermittent porphyria.
Performing Laboratory
Mayo Clinic Laboratories