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Paraneoplastic Pemphigus Ab, IgG
Test CodeLAB00455
Alias/See Also
LAB00455
Mayo TC: PNPAB
Mayo TC: PNPAB
CPT Codes
86255
Preferred Specimen
2.0 mL Serum
Marble/Gold/Red Top
Marble/Gold/Red Top
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Gross lipemia, Gross icterus
Methodology
Indirect Immunofluorescence Assay
Limitations
In the appropriate clinical setting, a positive result can support a diagnosis of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome (PNP/PAMS). However, correlation with clinical features, histopathologic findings, results of serum studies (such as indirect immunofluorescence on monkey esophagus substrate and ELISA for Dsg1/3) is required for a final diagnosis.
As the test is not entirely sensitive, a negative test result does not exclude the possibility of PNP/PAMS.
As the test is not entirely sensitive, a negative test result does not exclude the possibility of PNP/PAMS.
Reference Range
Paraneoplastic Pemphigus Antibody, IgG:
Negative
Negative
Clinical Significance
Diagnosis of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome in the setting of erosive or lichenoid mucocutaneous disease.
Performing Laboratory
Mayo Clinic Laboratories