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Adalimumab and Anti-Adalimumab Antibody, DOSEASSURE ADL
Test CodeLAB00502
Alias/See Also
LAB00502
LabCorp TC: 503890
Anti-TNF-alpha drug
Humira
LabCorp TC: 503890
Anti-TNF-alpha drug
Humira
CPT Codes
80145, 82397
Includes
Adalimumab+Ab (Serial Monitor) Adalimumab Drug Level
Anti-Adalimumab Antibody
Anti-Adalimumab Antibody
Preferred Specimen
2 mL Serum
(Marble, Gold, Red)
(Marble, Gold, Red)
Minimum Volume
1 mL
Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.
Transport Temperature
Frozen
Specimen Stability
Frozen: 308 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma specimen received
Methodology
Electrochemiluminescence Immunoassay (ECLIA)
Report Available
6-10 days
Limitations
In the absence of antiadalimumab antibodies, the adalimumab drug level typically reflects the total adalimumab concentration in serum. In the presence of antiadalimumab antibodies, the adalimumab level typically reflects the antibody-unbound fraction of adalimumab concentration in serum.
This assay provides clinically valid antibody results at drug levels well above treatment targets (>30 ug/mL). Failure of adalimumab therapy may not always be due to the presence of antiadalimumab antibodies. In addition, the absence of antiadalimumab antibodies does not guarantee positive response to treatment.
This assay provides clinically valid antibody results at drug levels well above treatment targets (>30 ug/mL). Failure of adalimumab therapy may not always be due to the presence of antiadalimumab antibodies. In addition, the absence of antiadalimumab antibodies does not guarantee positive response to treatment.
Clinical Significance
Monitor antiadalimumab therapy for individuals with Crohn's disease, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, or other autoimmune conditions. This test provides adalimumab drug concentration levels as well as the level of antiadalimumab antibodies.
Performing Laboratory
LabCorp