Test Code

CPT Codes

This test screens for and quantitates, if present, the following synthetic glucocorticoids: betamethasone, budesonide, dexamethasone, fludrocortisone, flunisolide, fluorometholone, megestrol acetate, methylprednisolone, prednisolone, prednisone, triamcinolone, and triamcinolone acetonide. The presence of synthetic glucocorticoids in serum indicates current or recent use of these compounds. Since several of these compounds exceed the potency of endogenous cortisol by 1 or more orders of magnitude, even trace levels may be associated with Cushingoid features.
NOTE:This assay does not detect fluticasone propionate.

Preferred Specimen

Minimum Volume
1.1 mL

Other Acceptable Specimens

Specimen Stability
Serum Frozen 14 days
  Refrigerated 7 days
  Ambient 24 hours

Setup Schedule
Tuesday, Thursday; 9 a.m.

Clinical Significance
Synthetic glucocorticoids are widely used and have important clinical utility both as anti-inflammatory and immunosuppressive agents. The medical use of these agents, as well as their surreptitious use, can sometimes lead to a confusing clinical presentation. Patients exposed to these steroids may present with clinical features of Cushing syndrome, but with suppressed cortisol levels and evidence of hypothalamus-pituitary-adrenal axis suppression.


This assay does not detect fluticasone propionate.

Performing Laboratory
Mayo Medical Laboratories 3050 Superior Drive NW Rochester, MN 55901

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.