T-Cell Receptor Gene Rearrangements, gamma and beta

Message

*Collect specimen Monday through Friday only before 1500 EST. Do not collect the day before a holiday.

Test Code

LAB00117

Alias/See Also

LAB00117
LabCorp TC: 481080
TCRB Gene Clonality Assay
TCRG Gene Clonality Assay

CPT Codes
81340, 81342

Preferred Specimen

5 mL Lavender (EDTA) - Whole Blood

Minimum Volume

0.5 mL Lavender (EDTA) - Whole Blood

Other Acceptable Specimens

Dark Green Top (Sodium Heparin) - Whole Blood
Yellow Top (ACD) - Whole Blood
1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen.

Transport Temperature

Refrigerated: Blood, Bone Marrow, Tissue in RPMI
Room Temperature: FFPE specimens

Methodology
Polymerase Chain Reaction (PCR)

Limitations

This PCR assay is able to detect a clonal DNA population at the sensitivity of 5% in a background of polyclonal DNA.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Clinical Significance

This profile can be used to detect clonal T-cell receptor γ-chain (TCRG) and β-chain (TCRB) gene rearrangements in blood, bone marrow, and tissue specimens with a combined T-cell clonality detection rate of 94% to 99%. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a T-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive conditions. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.

Performing Laboratory
LabCorp

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.