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Pyruvic Acid, Blood
MessageRetrieve pre-chilled tube from processing before drawing!
Patient fasting for at least 4 hours is required.
Patient fasting for at least 4 hours is required.
Test Code
LAB744
Alias/See Also
LAB744
Mayo TC: PYR
Mayo TC: PYR
CPT Codes
84210
Preferred Specimen
Special tube containing 2.5 mL of 6% perchloric acid (T012) found in processing .
WHOLE BLOOD
WHOLE BLOOD
Patient Preparation
Fasting is required.
Other Acceptable Specimens
None
Instructions
Collection Instructions:
1. Special collection tube must be prechilled prior to collection. Stored in the processing refrigerator. (Check the expiration date of tube.)
2. Draw enough blood directly into syringe to add exactly 1 mL of blood to the prechilled special collection tube.
3. Taking care to not spill any of the preservative, cautiously remove the cap from the tube.
4. Immediately tranfer blood, once drawn, to the prechilled, special collection tube, recap, and shake vigorously to mix.
If any perchloric acid (preservative) spills, obtain a new prechilled tube.
1. Special collection tube must be prechilled prior to collection. Stored in the processing refrigerator. (Check the expiration date of tube.)
2. Draw enough blood directly into syringe to add exactly 1 mL of blood to the prechilled special collection tube.
3. Taking care to not spill any of the preservative, cautiously remove the cap from the tube.
4. Immediately tranfer blood, once drawn, to the prechilled, special collection tube, recap, and shake vigorously to mix.
If any perchloric acid (preservative) spills, obtain a new prechilled tube.
Transport Container
Perchloric Acid-Pyruvate Tube (Mayo T012)
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 15 days
Methodology
Spectrophotometry (SP)
Report Available
4-8 days
Limitations
Correct specimen collection and handling is crucial to achieve reliable results.
Pyruvic acid levels alone have little clinical utility. Abnormal concentrations of pyruvic acid and lactate-to-pyruvate (L:P) ratios are not diagnostic for a particular disorder but must be interpreted in the context of the patient's clinical presentation and other laboratory studies. The determination of pyruvic acid is of diagnostic value when lactic acid is measured and the L:P ratio is established in the same specimen.
Pyruvic acid levels alone have little clinical utility. Abnormal concentrations of pyruvic acid and lactate-to-pyruvate (L:P) ratios are not diagnostic for a particular disorder but must be interpreted in the context of the patient's clinical presentation and other laboratory studies. The determination of pyruvic acid is of diagnostic value when lactic acid is measured and the L:P ratio is established in the same specimen.
Reference Range
Pyruvic Acid:
0.08-0.16 mmol/L
NIH Unit:
0.7-1.4 mg/dL
0.08-0.16 mmol/L
NIH Unit:
0.7-1.4 mg/dL
Clinical Significance
Pyruvic acid, an intermediate metabolite, plays an important role in linking carbohydrate and amino acid metabolism to the tricarboxylic acid cycle, the fatty acid beta-oxidation pathway, and the mitochondrial respiratory chain complex. Though isolated elevated pyruvate is not diagnostic of an inborn error of metabolism, analysis with lactate may suggest an inborn error of metabolism as some present with lactic acidosis or a high lactate-to-pyruvate (L:P) ratio.
Performing Laboratory
Mayo Clinic Laboratories
Additional Information
Mayo Pyruvic Acid, Blood