Leptospira Antibody IgM

Test Code

LAB1249

Alias/See Also

LAB1249
Mayo TC: LEPDT
Mayo Test Name: Leptospira, IgM, Serum

CPT Codes
86720

Preferred Specimen

1.0 mL Serum
Marble/Gold/Red

Minimum Volume

0.5 mL Serum

Instructions

If acute and convalescent specimens are being obtained to determine seroconversion, they should be collected 2 or more weeks apart.

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, Gross lipemia

Methodology
Enzyme-Linked Immunoassay Dot (Immunodot)

Report Available

1-5 days

Reference Range

Leptospira IgM:
Negative

Clinical Significance

Samples interpreted as negative indicate that antibody is not present in the sample, or is below the detection level of the method. Since antibodies may not be present during early disease, confirmation two to three weeks later is recommended. An initially-negative result followed by a positive result indicates IgM seroconversion. Equivocal specimens should be cautiously interpreted. Further testing with an additional specimen is recommended. If the specimen remains equivocal, a second serological method should be considered if leptospirosis infection is still suspected. Samples interpreted as positive may indicate the specific antibody. Antibody presence alone cannot be used for diagnosis of acute infection, however, because antibodies from prior exposure may circulate for a prolonged period of time.

Performing Laboratory
Mayo Clinic Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.