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Leptospira Antibody IgM
Test CodeLAB1249
Alias/See Also
LAB1249
Mayo TC: LEPDT
Mayo Test Name: Leptospira, IgM, Serum
Mayo TC: LEPDT
Mayo Test Name: Leptospira, IgM, Serum
CPT Codes
86720
Preferred Specimen
1.0 mL Serum
Marble/Gold/Red
Marble/Gold/Red
Minimum Volume
0.5 mL Serum
Instructions
If acute and convalescent specimens are being obtained to determine seroconversion, they should be collected 2 or more weeks apart.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Gross lipemia
Methodology
Enzyme-Linked Immunoassay Dot (Immunodot)
Report Available
1-5 days
Reference Range
Leptospira IgM:
Negative
Negative
Clinical Significance
Samples interpreted as negative indicate that antibody is not present in the sample, or is below the detection level of the method. Since antibodies may not be present during early disease, confirmation two to three weeks later is recommended. An initially-negative result followed by a positive result indicates IgM seroconversion. Equivocal specimens should be cautiously interpreted. Further testing with an additional specimen is recommended. If the specimen remains equivocal, a second serological method should be considered if leptospirosis infection is still suspected. Samples interpreted as positive may indicate the specific antibody. Antibody presence alone cannot be used for diagnosis of acute infection, however, because antibodies from prior exposure may circulate for a prolonged period of time.
Performing Laboratory
Mayo Clinic Laboratories