CELIAC

Message
TEST CODE "CELIAC" includes 3 tests:
IGA-SD CPT 82784
TR-IGAAB: CPT 83516
AGAB-IGG: CPT 83516


Test Code
CELIAC

CPT Codes
82784,83516X2

Includes
IMMUNOGLOBULIN A
TRANSGLUTAMINASE IGA AAB
ANTI-GLIADIN AB IGG

Preferred Specimen
SERUM

Instructions
SEND TO QUEST

Transport Container
MARBLE TOP

Transport Temperature
REF

Setup Schedule
Set Up:
Report Available:

Reference Range
TOTAL IGA1506
TRANSGLUTAMINASE IGA1029
GLIADIN IGG1261


Clinical Significance
A comprehensive evaluation for the antibodies associated with gluten sensitivity, characteristic of Celiac Disease. Celiac disease or gluten sensitive entropathy is a chronic condition that damages the lining of the small intestine and results in a malabsorption syndrome. Detection of antibodies to gliadin, one of the major protein components of gluten, is useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

Performing Laboratory
 QUEST DIAGNOSTICS-NICHOLS INST
 (SPECIALTY LABORATORIES,INC)
 27027 TOURNEY ROAD
 VALENCIA, CA  91355-5386
 



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.