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Celiac Panel
Test CodeLAB01061
Alias/See Also
LAB01061
Includes
Immunoglobulin IgA - LAB73 - Performed in-house if patient is >12 years old
Tissue Transglutaminase, IgA - LAB723
Gliadin (Deamidated) Antibody, IgE - LAB872
Tissue Transglutaminase, IgA - LAB723
Gliadin (Deamidated) Antibody, IgE - LAB872
Preferred Specimen
3.0 mL Serum
Marble/Gold/Red
Marble/Gold/Red
Minimum Volume
1.5 mL Serum
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 14 days
Methodology
Immunoassay
Report Available
2-6 days
Clinical Significance
A comprehensive evaluation for the antibodies associated with gluten sensitivity, characteristic of Celiac Disease. Celiac disease or gluten sensitive entropathy is a chronic condition that damages the lining of the small intestine and results in a malabsorption syndrome. Detection of antibodies to gliadin, one of the major protein components of gluten, is useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
Performing Laboratory
Immunoglobulin IgA - Performed at LMH for patients >12 years
Immunoglobulin IgA - Performed at Quest Diagnostics if <12 years
Tissue Transglutaminase IgA and Gliadin Antibody IgG - Performed at Quest Diagnostics