| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
ANTINUCLEAR ANTIBODY IF
Test CodeANA
Alias/See Also
LAB147
ANA
ANTINUCLEAR ANTIBODIES, IFA
ANA
ANTINUCLEAR ANTIBODIES, IFA
CPT Codes
86039
Includes
ANA Titer
IF POSITIVE ANA PATTERN IS DETURMINED
IF POSITIVE ANA PATTERN IS DETURMINED
Preferred Specimen
SERUM
Transport Container
GOLD SST
Transport Temperature
REF- 3 DAYS
Setup Schedule
Set Up:
Report Available:
Report Available:
Reference Range
| ANTINUCLEAR ANTIBODY |
Clinical Significance
Antinuclear antibodies (ANAs), also known as antinuclear factor or ANF are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced.
There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, mixed connective tissue disease,polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.
There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, mixed connective tissue disease,polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.
Performing Laboratory
LMH - Microbiology x3758 or 3759