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Aminolevulinic Acid Dehydratase
Message*Place specimen on wet ice and take to processing ASAP.
*Collect specimen Monday through Thursday only before 1430 EST. Do not collect the day before a holiday.
Abstinence from alcohol is essential for at least 24 hours prior to specimen collection as ethanol suppresses aminolevulinic acid dehydratase activity, leading to false-positive results.
*Collect specimen Monday through Thursday only before 1430 EST. Do not collect the day before a holiday.
Abstinence from alcohol is essential for at least 24 hours prior to specimen collection as ethanol suppresses aminolevulinic acid dehydratase activity, leading to false-positive results.
Test Code
LAB00154
Alias/See Also
LAB00154
Mayo TC: ALAD
Mayo Test Name: Aminolevulinic Acid Dehydratase, Whole Blood
Mayo TC: ALAD
Mayo Test Name: Aminolevulinic Acid Dehydratase, Whole Blood
CPT Codes
82657
Preferred Specimen
4.0 mL Dark Green Top (Sodium Heparin) - Whole Blood
Minimum Volume
3.0 mL Dark Green Top (Sodium Heparin) - Whole Blood
Other Acceptable Specimens
Lavender (EDTA)
Transport Temperature
Refrigerate
Specimen Stability
Refrigerate: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Enzymatic End point/Spectrofluorometric
Report Available
3-9 days
Limitations
False-positive values may result from enzyme degradation due to improper specimen handling.
This test is NOT useful for detecting lead intoxicataion.
This test is NOT useful for detecting lead intoxicataion.
Reference Range
Aminolevulinic Acid Dehydratase:
> or = 4.0 nmol/L/sec
3.5-3.9 nmol/L/sec (indeterminate)
<3.5 nmol/L/sec (diminished)
Abnormal results are reported with a detailed interpretation including an overview of the results adn their significance, a correlation to available clinicla information provided with the specimen, differential diagnosis, and recommendations for additional testing when indicated and available.
> or = 4.0 nmol/L/sec
3.5-3.9 nmol/L/sec (indeterminate)
<3.5 nmol/L/sec (diminished)
Abnormal results are reported with a detailed interpretation including an overview of the results adn their significance, a correlation to available clinicla information provided with the specimen, differential diagnosis, and recommendations for additional testing when indicated and available.
Clinical Significance
Aminolevulinic acid dehydratase (ALAD) activity can be inhibited in situations including hereditary tyrosinemia type 1, lead intoxication, and exposure to styrene, trichloroethylene, or bromobenzene. These causes should be ruled out when considering a diagnosis of ALAD deficiency porphyria (ADP). This method will not detect a decreased ALAD enzyme activity due to lead intoxication.
Performing Laboratory
Mayo Clinic Laboratories